No. Routine cleaning with soap and water or other, even stronger, cleansers will not affect the efficacy of the surface. Just avoid abrasives that would damage or physically wear the surface. And the surface of NanoTouch products is super hydrophilic so that water, oils, dirt and other contaminants are actively shed. We've conducted tests with full strength bleach and the cleanser simply sheets right off. We've even put oil on the surface, and then gave it a quick rinse with water...all the oil was gone with no wiping. While our surfaces are self-cleaning at a microscopic level, they can still become soiled and even stained if exposed to things like coffee or wine.